Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes
NU Nguyen, BD Stamper - Chemico-Biological Interactions, 2017 - Elsevier
Due to its widespread availability, acetaminophen (APAP) is the leading cause for drug-
induced liver injury in many countries including United States and United Kingdom. When
used as recommended, APAP is relatively safe. However, in overdose cases, increased
metabolism of APAP to N-acetyl-para-benzoquinoneimine (NAPQI), a reactive metabolite,
leads to glutathione (GSH) depletion, oxidative stress, and cellular injury. Throughout this
process, a variety of factors play important roles in propagating toxicity, including c-Jun N …
induced liver injury in many countries including United States and United Kingdom. When
used as recommended, APAP is relatively safe. However, in overdose cases, increased
metabolism of APAP to N-acetyl-para-benzoquinoneimine (NAPQI), a reactive metabolite,
leads to glutathione (GSH) depletion, oxidative stress, and cellular injury. Throughout this
process, a variety of factors play important roles in propagating toxicity, including c-Jun N …
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